IDRA 21 CAS 22503-72-6 / IDRA21 powder

Chemical name:  IDRA-21
CAS No.:  22503-72-6
Supplier:  Keolie Biotech
 Molecular Formula: C8H9ClN2O2S

Other name: (3R)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Store at:  Room temperature

Purity: 99% min

Appearance: White to off white powder

IDRA-21 is an ampakine drug and a benzothiadiazinederivative. IDRA-21 is a chiral molecule, with (+)-IDRA-21 being the active form.

IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10–30 times more potent than aniracetam in reversing cognitive deficits induced by  orscopolamine,and produces sustained effects lasting for up to 48 hours after a single dose.The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain.

IDRA-21 does not produce neurotoxicity under normal conditions,although it may worsen neuronal damage following global ischemia after stroke or seizures.

In comparison to the benzoylpiperidine derived ampakine drugs, IDRA-21 was more potent than CX-516, but less potent than CX-546. Newer benzothiadiazide derivatives with greatly increased potency compared to IDRA-21 have been developed,but these have not been researched to the same extent, with the benzoylpiperidine and benzoylpyrrolidine CX-series of drugs being favoured for clinical development, most likely due to more favourable toxicity profiles at high doses.

· Improved Memory · Increased Learning Ability · Improved Cognitive Processing                      · Heightened Reflexes · Heightened Perception · Reduced Anxiety · Reduced Depression