Keolie Supply USP 99% dimethyl isosorbide powder

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Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder
Keolie Supply USP 99% dimethyl isosorbide powder

Keolie Supply USP 99% dimethyl isosorbide powder

  • Item No.KL-isosorbide
    MOQ1 Kilogram
Tag  sourcing
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If over 500pcs, mass production will start until pre-production sample has been approved.

Est. 7 days production

Quick Details
Product name isosorbide
Application Pharmaceutical Raw Intermediates
Place of Origin CN;SHA
Usage Animal Pharmaceuticals
Brand Name Keolie
Appearance White Powder
Assay99%
Model Number KL-isosorbide
SampleAvailable
COAAvailable
CertificateISO
molecular weight 236.1363
Shelf Life 2 Years
Type Vitamins, Amino Acids and Coenzymes
Grade Standard Medicine Grade
CAS No. 652-67-5
Grade Phamaceutical Grade
Other Names 1,4:3,6-Dianhydro-D-glucitol
MFC6H10O4
EINECS No. 211-492-3
Purity99%min

Packaging & Delivery

Selling Units:
Kilogram

Keolie Supply USP 99% dimethyl isosorbide powderintroduce.jpgIsosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure

Item Name
Isosorbide Dinitrate
CAS NO.
87-33-2
Molecular Formula
C6H8N2O8
Molecular weight
236.14
Apparence
White powder
Purity
99%
Advantage
OEM;ODM
Certificate
GMP/ISO9001
Payment
Trade Assurance; L/C; T/T; Western Union

function.jpg

Mechanism of action

Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

 

Absorption

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

 

Target

Atrial natriuretic peptide receptor 1

 

Enzyme

1.Cytochrome P450 3A4
2.Cytochrome P450 2E1package&shipping.jpgcompany details.jpgcontact.jpg

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