Metadoxine reduces ethanol in the blood. The ethanol in the body is mainly converted to acetaldehyde by alcohol dehydrogenase (ADH), a small amount is converted to acetaldehyde by microsomal alcohol oxidase, and acetaldehyde is dehydrated by acetaldehyde dehydrogenase (ALDH). It is converted to acetic acid and finally oxidized to CO2 and H2O via a tricarboxylic acid cycle. Because the rate of ethanol metabolism depends mainly on the activity of metabolic enzymes in the liver, it should be related to the inhibition of the deactivation of alcohol dehydrogenase (ADH), which can maintain the ADH in the body, and studies have shown that metadoxine It can accelerate the excretion of ethanol and its metabolites acetaldehyde and ketone bodies through the kidneys.
Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine improves the clinical signs of acute alcohol intoxication and accelerates alcohol clearance from the blood.